Prime Minister Anthony Albanese will deliver the 16th annual Lowitja O'Donoghue Oration, hosted by the Don Dunstan Foundation.

Mr Albanese will be the first sitting Prime Minister to undertake the Orator role at the event, to be held on Monday, May 29, during National Reconciliation Week.

The Oration honours the influential Aboriginal leader, Dr Lowitja O'Donoghue AC CBE DSG, and seeks to highlight vital issues for Australia's Aboriginal and Torres Strait Islander peoples.

City of Adelaide Lord Mayor and Don Dunstan Foundation chair Dr Jane Lomax-Smith said the Foundation was honoured to host the Prime Minister, especially at such a critical time in the nation's history.

"The Oration gives voice to issues of equity and equality for Australia's First Peoples and right now, that is more important and pertinent than ever," Dr Lomax-Smith said.

"In a few months, Australians will vote in a referendum to change the future for Aboriginal and Torres Strait Islander people now, and for generations to come.

"This is an opportunity for people from a range of backgrounds to hear directly from the Prime Minister why a yes vote will advance reconciliation and close the gap between Aboriginal and non-Aboriginal people across the country."

The Oration is presented by the Don Dunstan Foundation in collaboration with Reconciliation SA; The University of Adelaide; Flinders University; the Lowitja Institute and the Lowitja O'Donoghue Foundation.