Affordable Art Fair will return to the Brisbane Showgrounds from May 7 to 10, bringing more than 55 independent galleries from across Australia together for a four-day event centred on buying and discovering original art.

The Magandjin/Brisbane fair, returning for its third year over the Mother's Day weekend, will again feature works priced from $100 to $10,000, with organisers expecting strong interest after more than 13,300 visitors attended last year's event and spent a record $3.3 million on art.

Among the galleries and collectives returning this year is Artists of Ampilatwatja, which is using the fair to place a stronger focus on remote Aboriginal art, community-run practice and the stories carried through painting.

The Indigenous presence remains a key part of the fair's broader program, with Artists of Ampilatwatja and Warlukurlangu Artists both highlighted through the event's Access Partner program.

For Alyawarr and Kaytetye artist Kathleen Nanima Rambler, the work being shown in Brisbane is grounded in bush medicine, landscape and family connection to Country.

She said the paintings reflect the continuing relationship between women in the community and the places they come from.

"It makes us proud to be sharing a country to other people who don't know about the land and what it does to keep us going," Ms Rambler said.

"And passing that knowledge down to young generations through our paintings and take them out Bush teach them hunting and show what part of the country they belong to.

"For me, it makes me proud to show my artwork to people don't know where I come from and which part of the Australian I live."

Her comments point to the role painting continues to play beyond the canvas, with artworks carrying knowledge about plants, place and cultural responsibility.

Ms Rambler said there were also clear boundaries around what should and should not be shared through art.

"The paintings that we do - we don't do sacred sites we only just do push medicines and landscape because we're told not to paint sacred sites because it's important to keep it secret," Ms Rambler said.

That decision sits within a wider community approach that has shaped how Artists of Ampilatwatja presents its work to audiences outside Central Australia.

Manager Meagan Jacobs said last year's exhibition in Magandjin showed there was still limited public understanding of remote Indigenous communities and how art centres operate.

She said returning to Brisbane was important because it gave the art centre a chance to speak directly to a different audience than the Indigenous art fairs it more commonly attends.

"We had an exhibition last year in Brisbane and it was really well received," Ms Jacobs said.

"We did realise that a lot of people in Brisbane didn't really know much about the artists of Ampilatwatja or really remote Indigenous communities and arts centres and how they operate.

"So we thought returning would be great because this audience will be unlike other audiences that we have because we do attend Indigenous art fairs normally."

Ms Jacobs added the art centre was community-owned, worked on a transparent 50-50 split with artists and supported more than 200 people through materials, workshops and day-to-day assistance.

The centre is also a social and practical space for women in the community, not only a place to paint.

"We have over 200 artists on our books... it's a 50-50 split... everything's transparent and the artists are fully informed about every decision we make, like coming to Brisbane Art Fair," Ms Jacobs said.

"We're ethically sourced artworks.

"We are predominantly female artists And our art centre is open arms to anybody in the community that wants to come in and paint or just maybe come in and have a mug of tea and sit down and have a yarn."

The artwork remains tied to daily life in the community, where bush medicine is still practised and painting continues to reflect country passed down through families.

Affordable Art Fair Brisbane runs from Thursday, May 7 to Sunday, May 10 at the Brisbane Showgrounds Exhibition Building with more information available on their website.