Opposition Leader Peter Dutton has unveiled his reshuffled frontbench, with Jacinta Nampijinpa Price the new opposition Indigenous Australians spokesperson.

Mr Dutton made the announcement on Tuesday after the portfolio was vacated by Julian Leeser, who resigned from his role to campaign for the "yes" case.

The opposition leader described Senator Price as a "fighter".

"She's a warrior for Indigenous Australians and she's a very proud (Northern) Territorian," he told reporters.

"She's always fought hard to improve the lives of Indigenous women and kids, and we've seen that just in recent days.

"I know that she'll do an outstanding job in leading the charge, but better practical outcomes for Indigenous Australians, not through the prime minister's Canberra voice bureaucracy."

Senator Price, who has been a vocal campaigner against an Indigenous voice in the constitution, said she was "very humbled, very grateful that the leadership has entrusted me".

Senator Kerrynne Liddle will take on the role of opposition spokeswoman for child protection and the prevention of family violence.

Mr Leeser congratulated Senator Price and Senator Liddle on their frontbench elevations.

"These are great appointments by Peter Dutton. I have worked closely with Jacinta and Kerrynne. Together they will make significant contributions to addressing the challenges being faced by regional and remote Indigenous communities," he said.