Labor MPs have reacted positively to the resignation of former shadow Attorney-General and former Minister for Indigenous Australians Julian Leeser, who quit the opposition's front bench earlier today.

Citing the "different position" he holds in comparison to the Liberal Party's 'no' stance on an Indigenous Voice referendum, Mr Leeser announced his resignation from the Liberal front bench on Tuesday morning.

Foreign Minister and acting Prime Minister Penny Wong, said Mr Leeser has "put his principles first" in deciding to move to the Liberal party back bench.

"Julian Leeser has shown real strength today. He's put his principles first, he's put his principles ahead of partisan politics," Ms Wong said at a press conference.

"He certainly knows as much about this issue as anyone, and he understands this is a once in a generation chance to make a real difference in the lives of Aboriginal and Torres Strait Islander people and to help close the gap."

Referring to Tasmanian Senator Bridget Archer, Tasmanian Premier Jeremy Rockliff and former New South Wales Premier Dominic Perrottet, Ms Wong forecast the likelihood of further Liberal Party MPs voting against the Liberal Party line.

"Of course, he's not the first liberal who we've seen do this," Ms Wong said.

"… and I suspect these Liberals will not be the last to break from Mr. Dutton's partisan, narrow position.

"A narrow position which really flies in the face of the generosity and the decency of the Australian people."

Mr Leeser's move to the back bench provides him with an opportunity to cast a conscience vote for the Indigenous Voice referendum, a position he has shown public support for both preceding and following his resignation.

Although currently on leave, Prime Minister Anthony Albanese made his thoughts on Mr Leeser's resignation clear, labelling the Liberal MPs choice to quit the shadow cabinet as a "principled decision".

"Julian Leeser has made a principled decision to campaign for a yes vote at the referendum, like so many people from all sides of politics who are approaching this process in good faith," Mr Albanese said via a Twitter post.

Mr Leeser's resignation supported the Prime Minister's expectation of an increasing number of Liberal and National voters turning their back on the party to show support for the upcoming referendum on a constitutionally enshrined Voice.

"I think Peter Dutton has underestimated the number of Liberal and National Party voters who will show generosity and goodwill and will vote yes in this referendum," Mr Albanese recently told Sky News.

"This isn't about politicians. This is now about every Australian having one vote, one value and I sincerely hope that we have a yes vote in the referendum later this year."

In a statement, federal Minister for Indigenous Australians Linda Burney also applauded Mr Leeser's decision to side with the yes campaign, citing the growing support for the campaign across the country.

"Julian Leeser has shown strength today in putting his principles ahead of politics," she said.

"His decision reflects his long-held commitment to constitutional recognition through a Voice.

"There is support for yes in our cities and suburbs and remote communities, among leaders of every faith, in Australians of all backgrounds."