Indigenous healthcare across Pilbara communities are the focus of a $5.5 million donation from resources giant BHP to Telethon.

The 2025 beneficiaries of the miner's biggest-ever donation were announced at an annual Telethon beneficiaries breakfast on Friday.

The East Pilbara-based Upstream Health Project is one of the programs to be run via the donation, which will benefit communities where BHP operates.

Run by Puntukurnu Aboriginal Media Service (PAMS), the project ensured there was a permanent, culturally appropriate maternal and child health service in the region.

The results are already having a life changing impact.

Single mother of five and Martu woman Jennifer Landi said PAMS was instrumental to helping her navigate multiple aspects of her life.

From maternal health services, specialist referrals, telehealth consultations, child support, and transportation to and from medical appointments - locally and to Perth - had been invaluable.

"Raising a child on your own is already difficult, but caring for multiple children is incredibly overwhelming," Jennifer said.

"I've been doing this on my own, and without PAMS clinical services and the Upstream Program, I don't know where we would be or if we would have made it this far."

PAMS has empowered Jennifer and many other women in her community through education on self-care and child health.

"Thanks to what we've learned, we can now raise awareness among other women on how to improve their health and that of their children," she said.

BHP's Telethon donation would also help fund the establishment of a Rare Care Centre Pilbara Hub, dedicated to earlier detection and intervention of rare diseases, and provide additional support for Julyardi Aboriginal Corporation in Hedland to expand its wraparound health services for vulnerable families.

BHP WA community manager Rachel Donkin said the company's social investment program were designed with an eye to the future.

"We are always looking at how we can make these communities not only better places to live and work, but sustainable, thriving and empowered centres for future generations," she said.

"Access to healthcare is a key part of that commitment and we are thrilled to partner with these incredible organisations to help improve long-term health outcomes."

Note: Jennifer's name has been changed to protect her identity.