Nywaigi woman Melisa Anderson expressed pride in her grandfather's legacy as the Neville Bonner Bridge officially opened to the public on Thursday, connecting the new Queen's Wharf precinct in Brisbane's CBD with South Bank.

Ms Anderson noted the significance of the bridge's dedication to her grandfather, especially for Indigenous people across the country.

"This is something so significant, especially for our Indigenous people – not only in Queensland, but across Australia – to have something as large as this dedicated to his memory," she said.

Neville Bonner was the first Indigenous person to serve as a federal senator, representing Queensland in the 1970s and 1980s.

"A lot of the work that he did was selfless," Ms Anderson said.

"I am very proud of what he has done here in Australia, not only for our Indigenous communities but also for our non-Indigenous folk as well."

Senator Bonner was a significant figure in advancing reconciliation and advocating for Indigenous rights in Australia.

The pedestrian bridge spans more than 300 metres across the Brisbane River, with its mast reaching 77 metres above sea level.

Approximately 10,000 pedestrians are expected to use the bridge daily, which features shading and an observation area with seating.

The bridge was funded by the consortium responsible for delivering the Queen's Wharf precinct and is now owned by the state government.

Premier Steven Miles praised the decision to name the structure after Mr Bonner, calling it a fitting tribute to a man who made significant contributions to reconciliation and Queensland.

"The bridge looks fantastic. I can't wait to see folks starting to enjoy it," Mr Miles said.

Cyclists and e-scooter users are not permitted on the cable-stayed bridge, which connects to the dining area of the Queen's Wharf precinct.

Queensland's Development Minister Grace Grace supported the decision to ban cyclists, citing safety concerns in the area.

Simon Crooks, project director for the Destination Brisbane Consortium, said the bridge took about three years to build, with construction challenges including the COVID-19 pandemic and the 2022 floods.

He emphasised that the bridge is designed for pedestrians due to its location in a food and beverage precinct, likening it to the cyclist restrictions on Queen Street Mall.

A government building previously named after the late Mr Bonner in the CBD was demolished as part of the Queen's Wharf redevelopment.