Charlie Cameron could be under an injury cloud after landing awkwardly in a marking contest early during Brisbane's away clash with Melbourne on Friday night.

After an electric start from the Dees threatened to sink the Lions from the outset, Cameron kicked Brisbane's second major to given them something to take into quarter time.

Moments later he was surrounded by trainers after hyperextending his left knee at the goal line when the ball reentered their front fifty.

Cameron played out the final minutes of the quarter looking a little ginger.

Melbourne livewire Kysaiah Pickett kicked his side's sixth goal just seconds after the incident.

The hosts led 6.2 (38) to 3.3 (21) at the first break.

Cameron is carrying a limp to start the second term.