NSW Police are appealing for public assistance to locate a man, woman and child missing from Sydney's west.

Luke Fry, 28, and Veronica Ratcliffe, 23, were last sighted at a Westmead fast-food eatery on Hawkesbury Road around 5 pm on Thursday, accompanied by their six-month-old daughter.

Parramatta City Police Area Command initiated inquiries after Mr Fry, Ms Ratcliffe and their daughter couldn't be located or contacted, with Police saying they hold concerns for their welfare.

Mr Fry is of Aboriginal/Torres Strait Islander appearance, stands at approximately 170-175cm, possesses a medium build, short black hair, and a full beard.

Ms Ratcliffe is also of Aboriginal/Torres Strait Islander appearance, is around 170cm tall with a thin build, blue eyes, and blonde hair, though she was wearing a black wig in a bun during her last sighting.

She was last seen wearing a black t-shirt & long pants.

The couple are known to frequent the Parramatta, Harris Park, Westmead, Balmain and Central Coast areas.

Members of the pubic with information regarding their whereabouts ae urged to contact Parramatta Police or Crime Stoppers on 1800 333 000.