NSW Police have appealed to the public for assistance in locating 25-year old Nathan Dargin, who is missing on the state's Central Coast.

Known to frequent the Hamilton and Newcastle CBD areas, Mr Dargin was last seen on Beaumont Street, Hamilton on the evening of Friday 29 March.

When he failed to return and could not be located or contacted, officers from Newcastle City Police District were notified and commenced inquiries into his whereabouts.

He is described as being of Aboriginal/Torres Strait Islander appearance, is approximately 185-190 centimetres tall, of a thin build, with shaved brown hair and brown eyes.

Both police and Mr Dargin's family hold concerns for his welfare as he lives with several conditions that require medical treatment.

Members of the public who may have seen Mr Dargin or have information on his whereabouts are urged to contact Newcastle Police Station on 02 4929 0999 or Crime Stoppers on 1800 333 000.