An Aboriginal woman has died in hospital three days after suffering a medical event in south Perth's Wandoo Rehabilitation Prison.

After suffering the event on December 21, the 41-year-old was provided first aid by prison officers until paramedics arrived via air ambulance.

The woman was then transferred to south Perth's Fiona Stanley Hospital where she was placed on life support for three days before passing away on Christmas Eve.

The Western Australian Department of Justice confirmed that its staff supported family members in spending time with the woman at Fiona Stanley Hospital until she passed away.

"I wish to offer my condolences to the family at this difficult time," said Western Australian Commissioner for Corrective Services Mike Reynolds.

"I trust they took some comfort in being able to say their goodbyes."

Initial reports suggest no suspicious circumstances surrounding the death, however the Department of Justice confirmed via statement that the woman's death would be fully investigated.

"As with all deaths in custody, police will provide a report to the coroner," the statement read.

Wandoo Rehabilitation Prison is Western Australia's first dedicated alcohol and other drug rehabilitation prison for women in custody.

As of 30 September, 20 Indigenous deaths in custody had been recorded nationwide in 2022.