A 35-year-old Aboriginal woman has died in Western Australia's Bandyup Women's Prison.

The woman was found unresponsive in her single-occupancy cell early Monday morning.

The WA Department of Justice said prison staff provided first aid to the woman before St John WA paramedics arrived.

She was declared deceased at the site.

The Department said preliminary reports indicate that there were no suspicious circumstances.

As is mandatory for all deaths in custody, WA Police will prepare a report for the State Coroner.

Megan Krakouer, director of the National Suicide Prevention and Trauma Recovery Project, told National Indigenous Times the death of the 35-year-old Aboriginal woman was "a tragedy and my thoughts are with her family, loved ones and community".

"Any death in prison is unacceptable and must be treated with the utmost seriousness," she said.

"There must be a full, independent investigation into what happened at Bandyup Women's Prison, and we must continue to confront the systemic issues that see Aboriginal people so heavily overrepresented in our justice system."

There have been more than 600 Indigenous deaths in custody in Australia since the Royal Commission into Aboriginal Deaths in Custody brought down its findings and issued over 300 recommendations for reform in 1991.

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