Filmed in Juru Country in Far North Queensland, viewers can expect breathtaking scenery, dark humour and quirky characters in Netflix's new original show Irreverent.

Coupled with a fish out of water American main character, audiences will laugh out loud at this new Aussie comedy.

A criminal now posing as a reverend, Mackenzie Boyd is on the run from the most dangerous crime family in Chicago.

He lands in Clump, a sleepy town in Far North Queensland, trying to both evade his past but also pass himself off as a legitimate reverend in his new parish.

Irreverent features a plethora of First Nations cast members who play a range of interesting characters.

Cast members include Redfern Now's Kylie Bracknell, Mystery Road's Wayne Blair, and Calen Tassone. First Nations representation is also apparent behind the scenes with the writer's room including Dunghutti woman Darlene Johnson.

Noongar actress Bracknell plays police officer Piper, a complex character who wears her heart on her sleeve.

Bracknell said she loved how the characters in Irreverent were so diverse without there being token First Nations characters.

"Some I love and admired about the audition piece and about the cast for Irreverent is that it's not spelled out," she said.

"It's not like, well these characters have to be Indigenous, these characters have to be Caucasian, it wasn't ever a focus point.

"It's really great to have so many Indigenous actors in the show that aren't specifically tagged to Indigenous characters.

"It's just nice to have people in there as quirk as they are."

Tassone, who plays Harry, said the characters in Irreverent were written with a lot of respect and care.

"You could easily see these characters as just being character who could have been played by anyone," he said.

"Which is something that is really rare because I think as First Nations actors we're kind of pigeonholed into playing the same sort of stereotypical characters that you see.

"I feel like these characters (in Irreverent), while being First Nations, are just characters in themselves with their own complexities."

Tassone said viewers are going to love Irreverent for it's exciting yet humorous plot.

"There's a lot of humour to go along with this cross-continental sort of comedy," he said.

"But at the centre of it is just a lot of heart and I think that's what people are going to connect with the most."

Irreverent is available to stream on Netflix and Peacock from December 4.